PTP1B, A Potential Target of Type 2 Diabetes Mellitus

Diabetes is one of the common metabolic diseases, mainly divided into two types, type 1 diabetes mellitus and type 2 diabetes mellitus. Insulin resistance is the main performance of type 2 diabetes mellitus which are relative to some gene mutation, genetics, obesity and so on. Protein-tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator in insulin signaling pathways that are implicated in metabolic diseases such as obesity and type 2 diabetes. Many evidences from clinical and basic researches show that the high expression of PTP1B induces insulin resistance. It appears that PTP1B is an effective target for the treatment of type 2 diabetes mellitus. In this review, we briefly introduce composition of PTP1B and the role of PTP1B in insulin signaling of type 2 diabetes mellitus. We also summarized recent research progress of PTP1B inhibitors used in therapy of type 2 diabetes mellitus. *Corresponding author: Wei Zou, Liaoning Key Laboratories of Biotechnology and Molecular Drug Research and Development, Dalian, 116081, China, Tel: 86-0411-85827080; E-mail: [email protected] Received September 01, 2016; Accepted September 13, 2016; Published September 21, 2016 Citation: Sun J, Qu C, Wang Y, Huang H, Zhang M, et al. (2016) PTP1B, A Potential Target of Type 2 Diabetes Mellitus. Mol Biol 5: 174. doi:10.4172/21689547.1000174 Copyright: © 2016 Sun J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.